Physiological Partial Aldosterone Resistance in Human Newborns

Physiological Partial Aldosterone Resistance in Human Newborns Running Title: Aldosterone resistance at birth

1Inserm, U693, Le Kremlin-Bicêtre, F-94276, France; 2Faculté de Médecine Paris-Sud, UMR-S693, Univ Paris-Sud 11, Le Kremlin-Bicêtre, F94276, France; 3Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, F-94275, France ; 4Service de Pédiatrie et Réanimation Néonatales, Hôpital Antoine Béclère, Assista...

Renin and aldosterone response in human newborns to acute change in blood volume.

Increased activity of the renin/aldosterone system in the neonatal period is now well established in both animals and man but the control mechanisms are poorly understood. We have monitored the plasma renin activity (PRA) and plasma aldosterone concentration (PAldo) in 14 infants undergoing 21 exchange transfusions. PRA and PAldo were measured before and at 5, 10, 15, 30, 45, and 60 minutes aft...

Renin and aldosterone response in human newborns to acute blood volume change.

Low renal mineralocorticoid receptor expression at birth contributes to partial aldosterone resistance in neonates.

The human neonatal period is characterized by renal immaturity with impaired capacity to regulate water and sodium homeostasis, resembling partial aldosterone resistance. Because aldosterone effects are mediated by the mineralocorticoid receptor (MR), we postulated that this hormonal unresponsiveness could be related to low MR expression in the distal nephron. We measured aldosterone and renin ...

The physiological basis for a method of assaying aldosterone in extracts of human urine.

Within the past two years aldosterone, an, extremely potent sodium-retaining steroid, has been isolated, structurally identified (1, 2) and subjected to numerous physiologic studies. This steroid has been isolated from adrenal tissue (3-5), from adrenal venous blood of animals (6, 7) and from human urine (8, 9). Over the past five years there has accumulated convincing evidence that the clinica...